01247nas a2200169   4500008004100000245024800041210006900289260000800358300001400366490000900380520046500389100002400854700002500878700002500903700002100928856012800949       2017                        eng d00aRoute to benzimidazol-2-ones via decarbonylative ring contraction of quinoxalinediones: application to the synthesis of flibanserin, A drug for treating hypoactive sexual desire disorder in women and marine natural product hunanamycin analogue0 aRoute to benzimidazol2ones via decarbonylative ring contraction   cAUG  a5137-51410 v 2  3 a<p>A simple and practical method to access a variety of benzimidazol-2-ones is reported here. A series of N-alkylsubstituted benzimidazol-2-ones were synthesized by decarbonylative ring contraction starting from corresponding quinoxalinediones for the first time. The utility of the method has been demonstrated by synthesizing recently approved controversial drug flibanserin (Addyi) and a urea analogue of marine antibiotic natural product hunanamycin-A.</p>1 aShingare, Rahul, D.1 aKulkarni, Akshay, S.1 aSutar, Revannath, L.1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/route-benzimidazol-2-ones-decarbonylative-ring-contraction-quinoxalinediones-application