01230nas a2200145   4500008004100000245018500041210006900226260000800295300001400303490000900317520058300326100001700909700002600926856013200952       2017                        eng d00aTotal synthesis of tetrahydroisoquinoline-based bioactive natural products laudanosine, romneine, glaucine, dicentrine, and their unnatural analogues isolaudanosine and isoromneine0 aTotal synthesis of tetrahydroisoquinolinebased bioactive natural  cAPR  a1655-16630 v 49 3 aStarting from suitably substituted homophthalic acids, total synthesis of titled alkaloids have been demonstrated in very good yields. The obtained natural products laudanosine and romneine were utilized to accomplish synthesis of two isoquinoline-based alkaloids glaucine and dicentrine. Base-induced selective generation of two different types of benzylic carbanions, their coupling reactions with 3,4-dimethoxybenzyl mesylate, and the regioselective iodination followed by intramolecular aryl-aryl coupling reactions to form the fused biaryl systems were the strategic steps.1 aJangir, Ravi1 aArgade, Narshinha, P.  uhttps://library.ncl.res.in/content/total-synthesis-tetrahydroisoquinoline-based-bioactive-natural-products-laudanosine-romneine