01439nas a2200157   4500008004100000245010200041210006900143260000800212300000800220490000700228520087100235100001401106700001501120700001601135856013001151       2018                        eng d00aSynthesis of hyaluronic acid hydrogels using click chemistry approach for biomedical applications0 aSynthesis of hyaluronic acid hydrogels using click chemistry app  cJAN  a1-80 v103 aHyaluronic acid (HA) is one of the most versatile biomaterial which forms an essential component of an extracellular matrix (ECM) and plays a vital role in wide variety of biological processes. Inherent biocompatibility, biodegradability and presence of functional groups for modification make it an attractive material for the synthesis of hydrogels for biological applications. In the present work, we have explored an azide-alkyne click chemistry approach for the preparation of HA hydrogels. Furthermore, we incorporated the hydrolysable carbonate ester linkages which are known to cleave in the physiological environment. The hydrogels with carbonate ester linkages and incubated with drug molecules can be used for the slow release of drug molecules. The hydrogels synthesized using azide alkyne click chemistry was characterized using NMR and IR spectroscopy.1 aGupta, N.1 aTiwari, N.1 aBadiger, M.  uhttps://library.ncl.res.in/content/synthesis-hyaluronic-acid-hydrogels-using-click-chemistry-approach-biomedical-applications