01306nas a2200145   4500008004100000245009200041210006900133260000800202300001700210520075800227100001500985700001801000700002101018856012101039       2019                        eng d00aTelescoped sequence of exothermic and endothermic reactions in multistep flow synthesis0 aTelescoped sequence of exothermic and endothermic reactions in m  cJAN  aArticle ASAP3 aA multistep sequential flow synthesis of isopropyl phenol is demonstrated, involving 4-step exothermic, endothermic, and temperature sensitive reactions such as nitration, reduction, diazotization, and high temperature hydrolysis. Nitration of cumene with fuming nitric acid produces 2- and 4-nitrocumene which are converted into respective cumidines by the hydrogenation using Pd/Ni catalyst in H-cube with gravity separation. Hydrolysis of in situ generated diazonium salts in the boiling acidic conditions is carried out using integration of flow and microwave-assisted synthesis. 58% of 4-isopropyl phenol was obtained. The sequential flow synthesis can be applied to synthesize other organic compounds involving this specific sequence of reactions.1 aSharma, Y.1 aNikam, A., V.1 aKulkarni, A., A.  uhttps://library.ncl.res.in/content/telescoped-sequence-exothermic-and-endothermic-reactions-multistep-flow-synthesis