01465nas a2200217   4500008004100000022001400041245012800055210006900183260000800252300001400260490000800274520068300282100002500965700002400990700002001014700002201034700002401056700002401080700002101104856012201125       2018                        eng d  a1523-706000aTotal synthesis and biological evaluation of cell adhesion inhibitors peribysin A and B: structural revision of peribysin B0 aTotal synthesis and biological evaluation of cell adhesion inhib  cNOV  a7003-70060 v 203 aTotal synthesis of potent cell-adhesion inhibitors peribysins A and B has been accomplished for the first time in racemic form. A Diels-Alder/aldol sequence to build the skeleton and decoration of the desired functionalities of the targeted natural products using highly stereoselective operations are the highlights. The structures of synthesized peribysins were fully characterized using spectral data and single-crystal X-ray analysis. Through this total synthesis, the initially proposed structure of peribysin B has been revised. Furthermore, the cell-adhesion inhibition potential of the scaffold (two peribysins + three analogues) was confirmed using anti-adhesion assay.1 aKalmode, Hanuman, P.1 aHandore, Kishor, L.1 aRajput, Raveena1 aShaikh, Samir, R.1 aGonnade, Rajesh, G.1 aKulkarni, Kiran, A.1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/total-synthesis-and-biological-evaluation-cell-adhesion-inhibitors-peribysin-and-b