01486nas a2200193   4500008004100000245011800041210006900159260000800228300001400236490000700250520076300257100002001020700002001040700002701060700003001087700001901117700002501136856013101161       2018                        eng d00a Ni-catalyzed alpha-alkylation of unactivated amides and esters with alcohols by hydrogen auto-transfer strategy 0 aNicatalyzed alphaalkylation of unactivated amides and esters wit  cNOV  a3911-39160 v113 aA transition-metal-catalyzed borrowing hydrogen/hydrogen auto-transfer strategy allows the utilization of feedstock alcohols as an alkylating partner, which avoids the formation of stoichiometric salt waste and enables a direct and benign approach for the construction of C-N and C-C bonds. In this study, a nickel-catalyzed alpha-alkylation of unactivated amides and ester (tert-butyl acetate) is carried out by using primary alcohols under mild conditions. This C-C bond-forming reaction is catalyzed by a new, molecularly defined nickel(II) NNN-pincer complex (0.1-1 mol %) and proceeds through hydrogen auto-transfer, thereby releasing water as the sole byproduct. In addition, N-alkylation of cyclic amides under Ni-catalytic conditions is demonstrated.1 aMidya, Siba, P.1 aRana, Jagannath1 aPitchaimani, Jayaraman1 aNandakumar, Avanashiappan1 aMadhu, Vedichi1 aBalaraman, Ekambaram  uhttps://library.ncl.res.in/content/ni-catalyzed-alpha-alkylation-unactivated-amides-and-esters-alcohols-hydrogen-auto-transfer