01430nas a2200145   4500008004100000245009800041210006900139260000800208300001500216490000900231520087700240100002301117700002201140856012201162       2018                        eng d00aRecent advances in the organocatalytic enantioselective synthesis of functionalized -lactones0 aRecent advances in the organocatalytic enantioselective synthesi  cSEP  a2333-2349 0 v13  3 a<p>This Focus Review highlights recent developments in the organocatalytic enantioselective synthesis of -lactone derivatives. Owing to the importance of -lactones as a heterocyclic motif that is present in a variety of natural products and biologically active molecules, several catalytic methods have been developed for the synthesis of these compounds in their enantiomerically pure form. Organocatalytic methods that employ N-heterocyclic carbenes (NHCs), cinchona alkaloids, isothioureas, 4-dimethylaminopyridine (DMAP) derivatives, and phosphines have allowed the highly enantioselective synthesis of -lactones from cheap and readily available starting materials. Moreover, the inherent strain in the four-membered ring of -lactones has also been utilized in further synthetic transformations, thus making -lactones a versatile intermediate in organic synthesis.</p>1 aMukherjee, Subrata1 aBiju, Akkattu, T.  uhttps://library.ncl.res.in/content/recent-advances-organocatalytic-enantioselective-synthesis-functionalized-lactones