01198nas a2200145   4500008004100000245013600041210006900177260000800246300001400254490000700268520060300275100002100878700002400899856012900923       2018                        eng d00aRuthenium-catalyzed regioselective alkenylation/tandem hydroamidative cyclization of unmasked quinazolinones using terminal alkynes0 aRutheniumcatalyzed regioselective alkenylationtandem hydroamidat  cAUG  a8906-89130 v833 a<p>Ruthenium-catalyzed amide directed C-sp2-H activation of the quinazolinone scaffold has been demonstrated, leading to the selective mono- or dialkenylation in moderate to good yields to achieve medicinally important stilbene containing quinazolinones. The terminal allcyne is utilized as a coupling partner, which resulted in the selective trans-alkene formation. Electron-deficient phenylacetylenes facilitate alkenylation followed by tandem hydroamidation of the newly generated trans double bond to provide novel quinazolinone alkaloids related to the Luotonine class of natural products.</p>1 aViveki, Amol, B.1 aMhaske, Santosh, B.  uhttps://library.ncl.res.in/content/ruthenium-catalyzed-regioselective-alkenylationtandem-hydroamidative-cyclization-unmasked