01877nas a2200157   4500008004100000022001500041245006100056210005900117260000800176300001400184490000700198520137300205100002101578700002401599856009601623       2018                        eng d  a1861-4728 00aHydrogen-bonding-assisted supramolecular metal catalysis0 aHydrogenbondingassisted supramolecular metal catalysis  cDEC  a3623-36460 v133 aThe process of catalyst screening and discovery still largely relies on traditional ligand-design approaches, which suffer from complex synthetic requirements and offer limited structural diversity. On the contrary, supramolecular chemistry offers the potential to harness multiple weak secondary interactions to deliver self-assembled catalysts with diverse structures or to orient substrates to achieve enzyme-like activity and selectivity. Herein, the application of hydrogen-bonding (H-bonding) interactions as a construction element and directing group in "supramolecular transition-metal catalysis" is critically reviewed and the current state-of-the-art in the field is presented. H-bonding interactions empower structurally simple ligands to deliver complex self-assembled catalysts, which have been found to catalyze a gamut of organic transformations, including hydroformylation, hydrogenation, and allylation reactions. As we will discuss, on many occasions, these supramolecular catalysts outperform their analogous covalently linked catalytic systems. The potential of H-bonding interactions as directing groups has recently been recognized by the scientific community and this Focus Review presents the role of hydrogen-bonding interactions in directing substrates to obtain excellent selectivities and activities in a range of catalytic transformations.1 aMote, Nilesh, R.1 aChikkali, Samir, H.  uhttps://library.ncl.res.in/content/hydrogen-bonding-assisted-supramolecular-metal-catalysis