01295nas a2200157   4500008004100000245010200041210006900143260000800212300001400220490000700234520070900241100001800950700002300968700002000991856012601011       2018                        eng d00a Nickel-catalyzed regioselective C(2)-H difluoroalkylation of indoles with difluoroalkyl bromides0 aNickelcatalyzed regioselective C2H difluoroalkylation of indoles  cSEP  a2516-25210 v133 aRegioselective C(2)-H difluoroalkylation of C-3 unsubstituted indoles with commonly available fluoroalkyl bromides is successfully achieved employing a simple nickel catalyst system, (DME)NiCl2/Xantphos. This methodology shows excellent regioselectivity and exhibits a broad substrate scope. Various functional groups, such as -OMe, -F, and -Br, are tolerated on the indole backbone to give the difluoroalkylated products in moderate to good yields. Preliminary mechanistic findings demonstrate that the reaction is homogeneous in nature and involves a radical manifold. Synthetic utility of this nickel-catalyzed method is demonstrated by synthesizing melatonin receptor antagonist Luzindole derivative.1 aSoni, Vineeta1 aSharma, Dipesh, M.1 aPunji, Benudhar  uhttps://library.ncl.res.in/content/nickel-catalyzed-regioselective-c2-h-difluoroalkylation-indoles-difluoroalkyl-bromides