01608nas a2200169   4500008004100000245010300041210006900144260000800213490000600221520097500227100001801202700002301220700001801243700002301261700002401284856013001308       2018                        eng d00a Flim-Map: gene context based identification of functional modules in bacterial metabolic pathways0 aFlimMap gene context based identification of functional modules   cSEP0 v93 aPrediction of functional potential of bacteria can only be ascertained by the accurate annotation of its metabolic pathways. Homology based methods decipher metabolic gene content but ignore the fact that homologs of same protein can function in different pathways. Therefore, mere presence of all constituent genes in an organism is not sufficient to indicate a pathway. Contextual occurrence of genes belonging to a pathway on the bacterial genome can hence be exploited for an accurate estimation of functional potential of a bacterium. In this communication, we present a novel annotation resource to accurately identify pathway presence by using gene context. Our tool FLIM-MAP (Functionally Important Modules in bacterial Metabolic Pathways) predicts biologically relevant functional units called 'GCMs' (Gene Context based Modules) from a given metabolic reaction network. We benchmark the accuracy of our tool on amino acids and carbohydrate metabolism pathways.1 aBhatt, Vineet1 aMohapatra, Anwesha1 aAnand, Swadha1 aKuntal, Bhusan, K.1 aMande, Sharmila, S.  uhttps://library.ncl.res.in/content/flim-map-gene-context-based-identification-functional-modules-bacterial-metabolic-pathways