01965nas a2200193   4500008004100000022001500041245010400056210006900160260000800229300001400237490000700251520128700258100001801545700002401563700001501587700001701602700002801619856012401647       2018                        eng d  a 2192-650600a Twelve-armed hexaphenylbenzene-based giant supramolecular framework for entrapping guest molecules0 aTwelvearmed hexaphenylbenzenebased giant supramolecular framewor  cNOV  a1032-10370 v833 a<p>Host-guest chemistry is a functional model in supramolecular chemistry for understanding specific process occurring in biological systems. Herein, we describe a rationally designed giant multiarmed hexaphenylbenzene (HPB)-based supramolecular frameworks which encapsulate a variety of guest molecules in the voids of their crystal lattice through the cooperative interplay of multivalency, noncovalent forces and backbone rigidity. In this connection, pseudo-axially substituted twelve-armed hexaphenylbenzene was synthesized and its molecular entrapping nature was studied by varying number of H-bond donor-acceptor sites in the arms. The per-methyl esterified HPB acted as a cavitand to include nonpolar and polar aprotic guests in its crystal structure via C-H center dot center dot center dot pi, C-H center dot center dot center dot O and C-H center dot center dot center dot N interactions. The corresponding amidated HPB showed unprecedented inclusion of ammonia and segregation of the guest molecules according to their polarity in the lattice. Furthermore, this molecular entrapping system has been used to obtain the crystal structure of a hitherto unproven 2-azaallenium intermediate, which had been proposed to be involved in aminomethylation of activated arenes.</p>1 aMadhu, Suresh1 aGonnade, Rajesh, G.1 aDas, Tamal1 aVanka, Kumar1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/twelve-armed-hexaphenylbenzene-based-giant-supramolecular-framework-entrapping-guest