01419nas a2200181   4500008004100000245011300041210006900154260000800223300001400231490000700245520074500252100002500997700002301022700001901045700001801064700002801082856012701110       2018                        eng d00aSynthesis and anticancer activity of conformationally constrained Smac mimetics containing pseudo beta turns0 aSynthesis and anticancer activity of conformationally constraine  cSEP  a3473-34760 v593 aHerein, we report synthesis and in vitro anticancer activity of conformationally constrained Smac mimetics containing reverse turn inducing motifs "Ant-Pro" and "sAnt-Pro". The synthesis of Smac analogs with diverse hydrophobic groups at the C-terminus was carried out using solution phase peptide synthesis. The synthesis of Ant-Pro containing analogs 3a-j was carried out by ring opening of benzoxazinones 7a-c, whereas, their sulfonamide counterparts 4a-h were synthesized by using routine acid-amine coupling reaction. In vitro anticancer studies against breast cancer cell line MDA-MB-231 revealed that some of the new analogs had better anticancer activity than the standard AVPI Smac tetrapeptide. (C) 2018 Published by Elsevier Ltd.1 aBaravkar, Sachin, B.1 aWagh, Mahendra, A.1 aPaul, Debasish1 aSantra, Manas1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/synthesis-and-anticancer-activity-conformationally-constrained-smac-mimetics-containing