01794nas a2200157   4500008004100000022001500041245009300056210006900149260000800218300001400226520120700240100002201447700002301469700002401492856012001516       2018                        eng d  a 1434-193X00aAccelerated and enantioselective synthesis of a library of p-stereogenic urea phosphines0 aAccelerated and enantioselective synthesis of a library of pster  cDEC  a6768-67793 aChiral phosphorus ligands play a central role in majority of the asymmetric transformations. However, access to chiral phosphorus ligands is limited due to their challenging synthesis. Reported here is a highly efficient and accelerated catalytic asymmetric synthesis of P-stereogenic urea containing phosphines leading to a small library of 18 chiral phosphorus compounds. Characteristic two doublets in a P-31 NMR spectrum, spectroscopic and analytical evidences authenticated the formation of [Pd-{(S,S) Me-FerroLANE}(m-phenylurea)(I)] complex. Indeed, [Pd-{(S,S) Me-FerroLANE}(m-phenylurea)(I)] was found to catalyze the C-P coupling reaction and quantitative conversion was observed within 18 hours. Under optimized conditions, iodophenyl urea's (2a-2j) were treated with secondary phosphines (1a-1c) in presence of [Pd-{(S,S) Me-FerroLANE}(m-phenylurea)(I)] to obtain P-stereogenic urea phosphines 5a-5r. The identity of these urea derived phosphines was unambiguously ascertained using a combination of spectroscopic and analytical methods. The catalyst tolerated various functional groups and yielded corresponding urea containing phosphines with an enantiomeric excess in the range of 15-62 %.1 aKoshti, Vijay, S.1 aGote, Ravindra, P.1 aChikkali, Samir, H.  uhttps://library.ncl.res.in/content/accelerated-and-enantioselective-synthesis-library-p-stereogenic-urea-phosphines