02126nas a2200241   4500008004100000022001400041245011400055210006900169260000800238300001000246490000600256520133800262653001901600653002501619653001101644653000901655653002001664100002201684700001501706700001801721700001901739856012601758       2018                        eng d  a2062-249X00aContinuous flow synthesis of micron size silica nanoparticles: parametric study and effect of dosing strategy0 aContinuous flow synthesis of micron size silica nanoparticles pa  cJUN  a59-670 v83 a<p>This work for the first time reports continuous flow synthesis of silica nano-particles of size over 1 mu m using a simple tubular reactor. The systematic approach involves the study of effect of various parameters like: ammonia concentration, water concentration, electrolyte concentraton, temperature, solvent, residence time and mode of TEOS injection over a wide range. A combination of ethanol and butanol was used as the medium with relatively lower polarity. Various process parameters were optimized to obtain highly monodispersed particles of size up to 600 nm and high yield (up to 90%). Attempts of reducing the reaction time by increasing temperature or concentrations of any of the reagents resulted in significant polydispersity and even in the formation of random shape agglomerates. At the optimized conditions almost complete conversion of TEOS happenned within 40 min and further growth of particles was achieved by adding TEOS using multipoint injection approach. While multipoint dosing resulted in the formation of very small number of secondary particles, the larger particles continued to grow beyond 800 nm. Further reduction in the polarity of reaction medium was achieved by adding 20% v/v of toluene, which without changing homogeneity of the solution resulted in particles as large as 0.9-1.1 mu m.</p>10aFlow synthesis10aMultipoint injection10asilica10aTEOS10aTubular reactor1 aJundale, Rajashri1 aBari, Atul1 aThara, Chinnu1 aKulkarni, Amol  uhttps://library.ncl.res.in/content/continuous-flow-synthesis-micron-size-silica-nanoparticles-parametric-study-and-effect