01964nas a2200145   4500008004100000245008400041210006900125260000800194300001400202490000700216520144400223100001901667700002401686856010801710       2018                        eng d00aProline-catalyzed asymmetric -amination in the synthesis of bioactive molecules0 aProlinecatalyzed asymmetric amination in the synthesis of bioact  cJUN  a1944-19560 v293 aThe direct -amination of carbonyl compounds using organocatalysts represents a powerful and atom-economical tool for asymmetric C-N bond formation. We describe a complete account of -functionalization of carbonyl compounds, through iterative sequential -aminoxylation/amination using electrophilic O and N sources, as well as sequential -amination/HWE reaction for enantio- and diastereoselective synthesis of both syn - and anti -1,3-aminoalcohols and 1,3-diamines. Additionally this protocol is further extended for the easy construction of alkaloids such as indolizidine, pyrrolizidine, and quinolizidine fused-ring systems just by tuning the chain length of the aldehyde used as a starting material. This methodology provides further scope to extrapolate it for a variety of naturally occurring hydroxylated monocyclic and fused bicyclic pyrrolidine and piperidine based alkaloids such as lentiginosine, epi -lentiginosine, dihydroxypyrrolizidine, (+)-deoxoprosophylline and (-)-deoxoprosopinine alkaloids. Furthermore, we have also uncovered proline-catalyzed anti -selectivity for the synthesis of 1,2-amino alcohols in -amination of aldehyde and one-pot indium-mediated Barbier type allylation of -hydrazino aldehydes to accomplish the total synthesis of clavaminols, sphinganine and spisulosine with reduced number of steps and with high overall yields. 1 Introduction 2 Application in the Total Synthesis of Alkaloids 3 Conclusion1 aKumar, Pradeep1 aSharma, Brijesh, M.  uhttps://library.ncl.res.in/content/proline-catalyzed-asymmetric-amination-synthesis-bioactive-molecules