01217nas a2200181   4500008004100000245010000041210006900141260000800210300001400218490000600232520053900238100002800777700002600805700002200831700002400853700002800877856013000905       2018                        eng d00aHelically structured peptide architecture engineered using dimedone as a rigid organic scaffold0 aHelically structured peptide architecture engineered using dimed  cMAR  a2776-27800 v33 aThis communication reports the use of a rigid organic scaffold to attach two unsymmetrical peptide chains on a single carbon atom. The approach describes the step-by-step attachment of peptide chains to the rigid dimedone template (5,5-dimethyl-1,3-cyclohexanedione) - a molecular scaffold that directs orientation of the peptide helices in a well-defined arrangement via intra-molecular hydrogen bonding. The overall topology of the final molecules was studied using CD spectroscopy which suggested existence of helical architecture.1 aNadimpally, Krishna, C.1 aMadica, Krishnaprasad1 aKotmale, Amol, S.1 aGonnade, Rajesh, G.1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/helically-structured-peptide-architecture-engineered-using-dimedone-rigid-organic-scaffold