01587nas a2200205   4500008004100000245012700041210006900168260000800237300001200245490000700257520081800264100003001082700002401112700002201136700002601158700002301184700002101207700002601228856012701254       2018                        eng d00aFacile and solvent-free domino synthesis of new quinolidinyl-2,4-thiazolidinones: antifungal activityand molecular docking0 aFacile and solventfree domino synthesis of new quinolidinyl24thi  cJAN  a622-6300 v183 aObjective: We have synthesized new quinolidinyl-thiazolidinones via Knoevenagel condensation-alkylation reaction, catalyzed by [Et3NH][HSO4]. The present approach offers several advantages such as higher yields, eco-friendly reaction condition and economic availability of the catalyst. 

Method: The newly synthesized compounds were evaluated for their in vitro antifungal activity against six fungal strains. Some of the synthesized conjugates displayed good to moderate antifungal activity. 

Conclusion: Again, the molecular docking study performed against the fungal sterol 14 alpha-demethylase (CYP51) showed an excellent binding affinity towards the enzyme which could rationalize the promising antifungal activity portrayed by these derivatives and provides a platform for structure based drug design.1 aSubhedar, Dnyaneshwar, D.1 aShaikh, Mubarak, H.1 aTupe, Santosh, G.1 aDeshpande, Mukund, V.1 aKhedkar, Vijay, M.1 aJha, Prakash, C.1 aShingate, Bapurao, B.  uhttps://library.ncl.res.in/content/facile-and-solvent-free-domino-synthesis-new-quinolidinyl-24-thiazolidinones-antifungal