01175nas a2200217 4500008004100000022001300041245015400054210007100208260000800279300001400287490000700301520036800308100001800676700002500694700002200719700001900741700002200760700002000782700002200802856013300824 2018 eng d a1359734500aTransition metal free regio-selective C–H hydroxylation of chromanones towards the synthesis of hydroxyl-chromanones using PhI(OAc)2 as the oxidant0 aTransition metal free regioselective C–H hydroxylation of chroma cFEB a2252-22550 v543 a

The chromanone scaffold is considered as a privileged structure in drug discovery. Herein, we report a highly efficient PhI(OAc)2 mediated regioselective, direct C–H hydroxylation of chromanones. This method offers easy access to substituted 6-hydroxy chromanones in moderate to good isolated yields, thus paving the way for their pharmaceutical studies.

1 aViswanadh, N.1 aGhotekar, Ganesh, S.1 aThoke, Mahesh, B.1 aVelayudham, R.1 aShaikh, Aslam, C.1 aKarthikeyan, M.1 aMuthukrishnan, M. uhttps://library.ncl.res.in/content/transition-metal-free-regio-selective-c%E2%80%93h-hydroxylation-chromanones-towards-synthesis