01323nas a2200205   4500008004100000245010100041210006900142260000800211300001400219490000700233520057900240100002200819700001900841700002400860700001900884700001900903700003500922700002800957856013200985       2018                        eng d00aConformational studies of Ant-Pro motif-incorporated cyclic peptides: gramicidin S and avellanin0 aConformational studies of AntPro motifincorporated cyclic peptid  cJAN  a1197-12010 v423 aThis paper reports conformational changes observed in cyclic bioactive peptides such as gramicidin S and avellanin upon incorporation of a pseudo-beta (C9) Ant-(D)Pro turn motif in their structural frameworks. Solution-state studies suggested that a synthetic gramicidin S analog exhibits a beta-sheet conformation with C9 and C17 intramolecular hydrogen bonding patterns, while its truncated analog disturbs the beta-sheet conformation. Structural details were obtained using a combination of CD studies, X-ray crystal structure studies and nOe-based MD simulation studies.1 aKotmale, Amol, S.1 aSangtani, Ekta1 aGonnade, Rajesh, G.1 aSarkar, Dhiman1 aBurade, Sachin1 aRajamohanan, Pattuparambil, R.1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/conformational-studies-ant-pro-motif-incorporated-cyclic-peptides-gramicidin-s-and-avellanin