01559nas a2200157   4500008004100000245015100041210006900192260000800261300001400269490000700283520091300290100002401203700002801227700002201255856012401277       2018                        eng d00aBismuth(III)-catalyzed cycloisomerization and (hetero)arylation of alkynols: simple access to 2-(hetero)aryl tetrahydrofurans and tetrahydropyrans0 aBismuthIIIcatalyzed cycloisomerization and heteroarylation of al  cMAY  a3229-32400 v163 a2-(Hetero)aryl tetrahydrofurans and tetrahydropyrans were successfully synthesized using Bi(OTf)(3)-catalyzed hydroalkoxylation (cycloisomerization) of alkynols (via 5 or 6 exo-dig cyclization) and intermolecular (hetero)arylation. This reaction involves a highly efficient cascade process, where initially the alkynol undergoes a cycloisomerization step via activation of the triple bond and generates the oxocarbenium ion, which subsequently participates in the (hetero)hydroarylation step with electron-rich arenes. Simple to complex suitably functionalized alkynols (4-pentyn-1-ols and 5-hexyn-1-ols) and electron-rich aromatic compounds were found to be reliable substrates in this cascade transformation and furnished a wide range of oxygen heterocycles. This practical tandem process provides a means to build libraries related to pharmacologically active molecules and natural product like scaffolds.1 aNakate, Ashwini, K.1 aPratapure, Madhukar, S.1 aKontham, Ravindar  uhttps://library.ncl.res.in/content/bismuthiii-catalyzed-cycloisomerization-and-heteroarylation-alkynols-simple-access-2