01468nas a2200181   4500008004100000245015200041210006900193260000800262300001000270490000800280520075300288100001801041700002501059700002701084700002301111700002401134856012801158       2018                        eng d00a Lithium hydride as an efficient reagent for the preparation of 1,2-anhydro inositols: does the reaction proceed through 'axial rich' conformation?0 aLithium hydride as an efficient reagent for the preparation of 1  cJUL  a32-360 v4633 ascyllo-Inositol derived 1,2-trans-diequatorial halohydrins can be efficiently converted to the corresponding epoxides in the presence of lithium hydride. The structure of one of the epoxides was determined by single crystal X-ray diffraction analysis. This provides a potential route for the preparation of ring modified inositol derivatives. DFT calculations suggest that this epoxide formation could be proceeding through the intermediacy of the cyclohexane ring-inverted axial-rich conformer (1,2-trans-diaxial halohydrin). This is supported by the results of DFT calculations on the formation of inositol orthoformate, where the product is locked in the axial-rich conformation, while the starting inositol has the equatorial-rich conformation.1 aSarkar, Nitai1 aSardessai, Richa, S.1 aShashidhar, Mysore, S.1 aTamboli, Majid, I.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/lithium-hydride-efficient-reagent-preparation-12-anhydro-inositols-does-reaction-proceed