01559nas a2200193   4500008004100000022001400041245012400055210006900179260000800248300001400256490000700270520084900277100002401126700002501150700002401175700002101199700002501220856012001245       2018                        eng d  a1144-054600aX-ray crystal structures and anti-breast cancer property of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acids0 aXray crystal structures and antibreast cancer property of 3tertb  cJAN  a1078-10860 v423 a<p>Diastereomeric `2RS, 4R'-2-arylthiazolidine-4-carboxylic acids (ATCAs) were synthesized and their resolution to chiraly pure N-BOC derivatives was attempted by column chromatography. The absolute stereochemistry of the resolved compounds was ascertained by X-ray single crystal structures. Further application of the synthesized compounds was studied for their in vitro anti-breast cancer activity against MCF7 cell line using DOX as a standard by MTT assay method. Cell morphology analysis was carried out by fluorescence microscopy. The compounds containing `2S' absolute configuration in thiazolidine ring and presence of 2-NO2, 2,6-Cl groups on `2R'-aryl substituent showed significant antibreast cancer activity where some of the compounds were found to be more active than DOX in terms of induced apoptosis mode of MCF7 cell death.</p>1 aJagtap, Rohidas, M.1 aThorat, Shridhar, H.1 aGonnade, Rajesh, G.1 aKhan, Ayesha, A.1 aPardeshi, Satish, K.  uhttps://library.ncl.res.in/content/x-ray-crystal-structures-and-anti-breast-cancer-property-3-tert-butoxycarbonyl-2