01387nas a2200157   4500008004100000245008100041210006900122260000800191300001400199490000700213520081400220100002201034700003701056700002401093856011201117       2017                        eng d00aPotent antimicrobial activity of lipidated short alpha,gamma-hybrid peptides0 aPotent antimicrobial activity of lipidated short alphagammahybri  cOCT  a1610-16150 v123 aHerein we report the potent antimicrobial activity of alpha,gamma-hybrid lipopeptides composed of 1:1 alternating - and gamma-amino acids. Along with their potent antimicrobial activity against various Gram-positive and Gram-negative bacteria, these hybrid lipopeptides were found to be less hemolytic. Studies into the mechanism of action revealed that these short cationic lipopeptides bind and disrupt the bacterial cell membrane. Time-kill kinetics analyses revealed that the potent alpha,gamma-hybrid lipopeptides completely inhibit bacterial growth in less than 20 minutes. Overall, the promising antimicrobial activity along with lower hemolytic activity displayed by these alpha,gamma-hybrid lipopeptides make them well suited for further exploration into the design of potent lipopeptide antibiotics.1 aBenke, Sushil, N.1 aThulasiram, Hirekodathakallu, V.1 aGopi, Hosahudya, N.  uhttps://library.ncl.res.in/content/potent-antimicrobial-activity-lipidated-short-alphagamma-hybrid-peptides