02566nas a2200193   4500008004100000245013000041210006900171260000800240300001600248490000700264520184300271100002702114700001902141700001602160700002402176700002602200700001702226856012902243       2017                        eng d00aChiral discrimination through h-1 nmr and luminescence spectroscopy: dynamic processes and solid strip for chiral recognition0 aChiral discrimination through h1 nmr and luminescence spectrosco  cDEC  a18303-183130 v233 aThe appropriate choice of the host molecules with well-defined optical activity (S-H/R-H) helps in the differentiation between two secondary ammonium ion-derivative guest molecules with different optical activities (R-G/S-G) based on the fluorescence resonance energy transfer (FRET)based luminescence responses. Crown ether-based host molecules with opposite chiral configurations (R-H, S-H) have been derived from 1,1'-bi-2-naphthol (BINOL) derivatives that have axially chiral biaryl centers. These chiral crown ethers form host-guest complexes (i.e., [2] pseudoro-taxanes) with chiral secondary ammonium ion derivatives (R-G, S-G). NMR spectroscopic studies show that the complexes are in a dynamic equilibrium in solution. Results of the H-1 NMR and fluorescence spectroscopic studies indicate a head-on orientation of the host and guest in the [2] pseudorotaxanes. The difference in the efficiency in the FRET-based responses between anthracene and the BINOL derivatives allow efficient chiral discrimination of the guests. Isothermal titration calorimetry and NMR investigations reveal that inclusion complexes between hosts and guests of the same chirality (R-H center dot R-G, S-H center dot S-G) are more stable relative to those of opposite chirality (R-H center dot S-G, S-H center dot R-G). However, FRET-based energy-transfer efficiency is higher for R-H center dot S-G and S-H center dot R-G complexes. NMR spectroscopic studies show that the relative orientation of the guest in the host cavity is significantly different when the host binds a guest of the same or opposite chirality; furthermore, the latter is more favorable for FRET, thus enabling discrimination between enantiomers. Interestingly, chiral discrimination of guest ions could also be achieved by using silica surfaces modified with chiral host molecules.1 aGangopadhyay, Monalisa1 aMaity, Arunava1 aDey, Ananta1 aRajamohanan, P., R.1 aRavindranathan, Sapna1 aDas, Amitava  uhttps://library.ncl.res.in/content/chiral-discrimination-through-h-1-nmr-and-luminescence-spectroscopy-dynamic-processes-and