01299nas a2200217   4500008004100000245007600041210006900117260000800186300001200194490000700206520063500213100001600848700001800864700001200882700001800894700001700912700001600929700001700945700001500962856010400977       2017                        eng d00aRepurposing Ivacaftor for treatment of staphylococcus aureus infections0 aRepurposing Ivacaftor for treatment of staphylococcus aureus inf  cSEP  a389-3920 v503 a<p>Drug repurposing of non-antimicrobials is a novel method to augment a seriously depleted drug pipeline for targeting drug–resistant pathogens. This article highlights the potent antimicrobial activity of Ivacaftor against Staphylococcus aureus, including vancomycin– and other multidrug–resistant strains. The potent activity of Ivacaftor in vivo is also demonstrated in a murine neutropenic thigh infection model. Taken together, these results support the potential of Ivacaftor as an antimicrobial agent for the treatment of staphylococcal infections. © 2017 Elsevier B.V. and International Society of Chemotherapy</p>1 aThakare, R.1 aSingh, A., K.1 aDas, S.1 aVasudevan, N.1 aJachak, G.R.1 aReddy, D.S.1 aDasgupta, A.1 aChopra, S.  uhttps://library.ncl.res.in/content/repurposing-ivacaftor-treatment-staphylococcus-aureus-infections