01395nas a2200157   4500008004100000245014800041210006900189260000800258490000700266520074400273100002001017700002301037700002201060700002801082856012701110       2017                        eng d00aThree in one: prototropy-free highly stable AADD-type self-complementary quadruple hydrogen-bonded molecular duplexes with built-in fluorophore0 aThree in one prototropyfree highly stable AADDtype selfcomplemen  cFEB0 v533 aThis communication reports an effective approach for addressing the prototropy-related problems in heterocycle-based AADD-type self-assembling systems by freezing their hydrogen-bonding codes, by utilizing intramolecular bifurcated hydrogen bonding interactions. Using this strategy, we have also developed a hydroquinone-conjugated AADD-type self-assembling system adorned with three valuable features such as prototropy-free dimerization yielding single duplexes, high duplex stability and a built-in fluorophore, which would augment its application potential. The rational approach used herein to arrest prototropic shift may also find application elsewhere, wherein proton shift-mediated structural changes become a detrimental factor.1 aKheria, Sanjeev1 aRayavarapu, Suresh1 aKotmale, Amol, S.1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/three-one-prototropy-free-highly-stable-aadd-type-self-complementary-quadruple-hydrogen