01578nas a2200145   4500008004100000245009900041210006900140260000800209300001600217490000700233520102000240100002701260700002001287856012501307       2017                        eng d00aEpalrestat-cytosine cocrystal and salt structures: attempt to control E,Z -> Z,Z isomerization0 aEpalrestatcytosine cocrystal and salt structures attempt to cont  cMAY  a3350–33600 v173 aCocrystallization of the anti-diabetic drug Eparlestat (EPR) with cytosine (CYT) gave EPR‒‒CYT-H+ form I, a salt-cocrystal hybrid structure, salt hydrate (EPR‒‒CYT-H+‒H2O, 1:2:1), and non-stoichiometric solvates of EPR‒‒CYT-H+ with EtOH/n-PrOH included in the rhombohedral symmetry voids, referred to as form II. Desolvation of EPR‒‒CYT-H+ form II solvates resulted in an unsolvated form II of EPR‒‒CYT-H+ which was characterized by DSC, TGA and NMR. The carboxylate•••cytosinium synthon was observed in the salts structure along with the uncommon CYT-H+•••H+-CYT base pairing in the structures of salt-cocrystal hybrid and salt hydrate. The crystalline forms were characterized by spectroscopic (IR, NMR), thermal (DSC, HSM, TGA), powder X-ray diffraction (PXRD) and single crystal X-ray diffraction (SC-XRD) techniques. The intent of using the salt/ salt-cocrystal forms as a means to stop the E,Z  Z,Z isomerization of EPR was not successful in photo-irradiation experiments.1 aNangia, Ashwini, Kumar1 aBattini, Swapna  uhttps://library.ncl.res.in/content/epalrestat-cytosine-cocrystal-and-salt-structures-attempt-control-ez-zz-isomerization