01378nas a2200301 4500008004100000022001400041245008300055210006900138260000800207300001500215490000700230520045900237653001500696653002400711653001300735653002000748653001200768653001800780653001200798653001600810653001600826653003000842100002200872700002000894700002600914700002500940856011100965 2017 eng d a1477-052000aNickel-catalyzed N-vinylation of heteroaromatic amines via C-H bond activation0 aNickelcatalyzed Nvinylation of heteroaromatic amines via CH bond cSEP a 6896-69000 v153 a

Here, we report a ligand- and reductant-free nickel-catalyzed N-vinylation of heteroaromatic amines using biorenewable p-cymene as a solvent. This unprecedented cross-coupling strategy has high functional group tolerance (halides, alkoxy, cyano, chiral motif, etc.) and proceeded via C-H bond activation.

10aAlkylation10aAmination Reactions10aAnilines10aAryl Chlorides10ahalides10aMonoarylation10aO Bonds10aPrecatalyst10aPyrimidines10aRemoveble Directing Group1 aLandge, Vinod, G.1 aRana, Jagannath1 aSubaramanian, Murugan1 aBalaraman, Ekambaram uhttps://library.ncl.res.in/content/nickel-catalyzed-n-vinylation-heteroaromatic-amines-c-h-bond-activation