01753nas a2200229   4500008004100000245008300041210006900124260000800193300001200201490000800213520098800221100002301209700002101232700002401253700002501277700002501302700002001327700001901347700001901366700002301385856011501408       2017                        eng d00aSynthesis and antimycobacterial screening of new thiazolyl-oxazole derivatives0 aSynthesis and antimycobacterial screening of new thiazolyloxazol  cMAY  a333-3400 v1323 a<p>In the present study a series of 4-methyl-2-aryl-5-(2-aryl/benzyl thiazol-4-yl) oxazole (4a-v) have been synthesized and evaluated for their preliminary antitubercular, antimicrobial and cytotoxicity activity. Among all the synthesized compounds, 4v reported comparable activity against dormant M. tuberculosis H37Ra and M. bovis BCG strains with respect to standard drug rifampicin. The active compounds from the antitubercular study were further tested for anti-proliferative activity against HeLa, A549 and PANC-1 cell lines using MU assay and showed no significant cytotoxic activity at the maximum concentration evaluated. Further, the synthesized compounds were found to have potential antibacterial activities with MIC range of 2.1-26.8 mu g/mL. High potency, lower cytotoxicity and promising antimycobacterial activity suggested that these compounds could serve as good leads for further optimisation and development. (C) 2017 Elsevier Masson SAS. All rights reserved.</p>1 aAbhale, Yogita, K.1 aSasane, Amit, V.1 aChavan, Abhijit, P.1 aShekh, Saddam, Husen1 aDeshmukh, Keshav, K.1 aBhansali, Sujit1 aNawale, Laxman1 aSarkar, Dhiman1 aMhaske, Pravin, C.  uhttps://library.ncl.res.in/content/synthesis-and-antimycobacterial-screening-new-thiazolyl-oxazole-derivatives