01064nas a2200145   4500008004100000245012400041210006900165260000800234300001400242490000700256520048400263100002300747700002200770856012600792       2016                        eng d00aProline catalyzed enantioselective synthesis of (2S,3S)-3-hydroxypipecolic acid and formal synthesis of (+)-swainsonine0 aProline catalyzed enantioselective synthesis of 2S3S3hydroxypipe  cMAY  a2021-20240 v573 aA short enantioselective synthesis of (2S,3S)-3-hydroxypipecolic acid (overall yield: 18.8%; 96% ee) and formal synthesis of (+)-swainsonine (overall yield: 13.6%; 96% ee) have been described starting from commercially available acrolein. The synthetic strategy involves a high enantioselective L-proline catalyzed sequential c-amination and diastereoselective (dr > 99:1) Barbier allylation of aldehyde in one-pot as the key reaction. (C) 2016 Elsevier Ltd. All rights reserved.1 aAher, Ravindra, D.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/proline-catalyzed-enantioselective-synthesis-2s3s-3-hydroxypipecolic-acid-and-formal-0