01668nas a2200169   4500008004100000245017400041210006900215260000800284300001400292490000600306520095100312100002501263700002501288700002901313700002601342856013001368       2016                        eng d00aAsymmetric transfer hydrogenation of cyclic imines in water with a versatile hydrogen donorformic acid/N-methylpiperidine: rapid access to highly enantioselective amines0 aAsymmetric transfer hydrogenation of cyclic imines in water with  cJUL  a2221-22240 v13 aAsymmetric transfer hydrogenation (ATH) of cyclic imines in water has been investigated for the first time by using HCOOH in combination with bases other than triethylamine as H donor. Effect of FA/Base ratio has shown significant impact on activity and enantioselectivity for ATH reaction in water. Use of methanol as a co-solvent improved the reduction performance. FA/N-methylpiperidine was found to be excellent, versatile hydrogen donor for ATH of imine 6,7-dimethoxy-1-methyl-3,4-dihy-droisoquinoline (1a) giving by far the highest noted TOF value of 5940 h(-1). ATH of-different imines derivatives including 3, 4-dihydoisoquinolines, beta-carbolines and cyclic sulfonyl imines have been performed with excellent activity (91-99% yield) and enantioselectivity (88-97%) in very short time (1-2 min). This is very simple protocol for rapid access to enantioselective amines with very new and versatile hydrogen donor 1.1 FA/Nmethylpiperidine.1 aShende, Vaishali, S.1 aShingote, Savita, K.1 aDeshpande, Sudhindra, H.1 aKelkar, Ashutosh., A.  uhttps://library.ncl.res.in/content/asymmetric-transfer-hydrogenation-cyclic-imines-water-versatile-hydrogen-donorformic-acidn