01054nas a2200145   4500008004100000245012200041210006900163260000800232300001400240490000700254520047300261100002400734700002500758856012500783       2017                        eng d00aApplication of unusual grignard reaction for the stereoselective synthesis of antidepressant drug (R)-(-)-venlafaxine0 aApplication of unusual grignard reaction for the stereoselective  cMAR  a1410-14180 v493 aAn enantioselective synthesis of antidepressant drug (R)-(-)-venlafaxine is accomplished as an application of recently explored unusual Grignard reaction. An innovative method for the generation of chirality at extremely reactive benzylic center along with determination of absolute stereochemistry has been discussed. The key steps involved in the synthesis include Sharpless asymmetric dihydroxylation for the induction of chirality and an unusual Grignard reaction.1 aChavan, Subhash, P.1 aKhatod, Harshali, S.  uhttps://library.ncl.res.in/content/application-unusual-grignard-reaction-stereoselective-synthesis-antidepressant-drug-r