01944nas a2200181   4500008004100000245011200041210006900153260000800222300002200230490000700252520126400259100001601523700002501539700002601564700002301590700002001613856012901633       2017                        eng d00aTubulointerstitial nephritis antigen-like 1 protein is downregulated in the placenta of pre-eclamptic women0 aTubulointerstitial nephritis antigenlike 1 protein is downregula  cMAR  aArticle Number: 80 v143 aBackground: Tubulointerstitial nephritis antigen-like 1 protein (TINAGL1), is a matricellular protein, known to play role in cell adhesion and cell receptor interaction. Research related to TINAGL1 is limited to cell culture and animal models. Demonstration of TINAGL1 as a positive regulator of angiogenesis and its expression in the decidua of postimplantation mouse uterus, prompted us to validate its expression in human placenta during impaired angiogenesis in pre-eclamptic condition. 
Methods: Placental tissue from normotensive (n = 25) and pre-eclamptic (n = 25) pregnancies were used to study the differentially expressed proteins by two-dimensional gel electrophoresis and TINAGL1 protein was validated with Western blotting. 
Results: A total of 55 protein spots were differentially expressed (fold change > 1.5, p < 0.05), of which 27 were upregulated and 28 were downregulated in the pre-eclamptic placenta. TINAGL1 was found to be downregulated in pre-eclamptic compared to normotensive pregnant women. 
Conclusion: This is the first study reporting TINAGL1 to be present in human placenta and differentially expressed in pre-eclamptic condition. The functional role of TINAGL1 in association to human pregnancy needs to be explored further.1 aMary, Sheon1 aKulkarni, Mahesh, J.1 aMehendale, Savita, S.1 aJoshi, Sadhana, R.1 aGiri, Ashok, P.  uhttps://library.ncl.res.in/content/tubulointerstitial-nephritis-antigen-1-protein-downregulated-placenta-pre-eclamptic-women