02245nas a2200205   4500008004100000245010700041210006900148260000800217300001400225490000800239520152600247100001901773700002801792700001701820700002401837700001601861700002201877700002001899856012001919       2017                        eng d00aTargeted drug delivery in covalent organic nanosheets (CONs) via sequential postsynthetic modification0 aTargeted drug delivery in covalent organic nanosheets CONs via s  cMAR  a4513-45200 v1393 aCovalent organic nanosheets (CONs) have emerged as a new class of functional two-dimensional (2D) porous organic polymeric materials with a high accessible surface, diverse functionality, and chemical stability. They could become versatile candidates for targeted drug delivery. Despite their many advantages, there are limitations to their use for target specific drug delivery. We anticipated that these drawbacks could be overturned by judicious postsynthetic modification steps to use CONs for targeted drug delivery. The postsynthetic modification would not only produce the desired functionality, it would also help to exfoliate to CONs as well. In order to meet this requirement, we have developed a facile, salt-mediated synthesis of covalent organic frameworks (COFs) in the presence of p-toluenesulfonic acid (PTSA). The COFs were subjected to sequential postsynthetic modifications to yield functionalized targeted CONs for targeted delivery of 5-fluorouracil to breast cancer cells. This postsynthetic modification resulted in simultaneous chemical delamination and functionalization to targeted CONs. Targeted CONs showed sustained release of the drug to the cancer cells through receptor mediated endocytosis, which led to cancer cell death via apoptosis. Considering the easy and facile COF synthesis, functionality based postsynthetic modifications, and chemical delamination to CONs for potential advantageous targeted drug delivery, this process can have a significant impact in biomedical applications.1 aMitra, Shouvik1 aSasmal, Himadri, Sekhar1 aKundu, Tanay1 aKandambeth, Sharath1 aMath, Kavya1 aDiaz, David, Diaz1 aBanerjee, Rahul  uhttps://library.ncl.res.in/content/targeted-drug-delivery-covalent-organic-nanosheets-cons-sequential-postsynthetic