01077nas a2200145   4500008004100000245010700041210006900148260000800217300001400225490000700239520050500246100003100751700002100782856012800803       2017                        eng d00aTotal synthesis of natural fregenedadiol and its diacetate, rearranged labdanes with aromatized B ring0 aTotal synthesis of natural fregenedadiol and its diacetate rearr  cMAR  a1262-12640 v583 aLabdane based natural products are most abundant and widely distributed in nature with many compounds exhibiting exceptional biological properties. Fregenedadiol is a bicyclic diterpene isolated from Halimium viscosum and represents a new carbon skeleton fregenedane with its B ring aromatized. Here, we report a total synthesis of this interesting natural product using one-pot Diels-Alder/aromatization sequence and selective hydrogenolysis as key steps. (C) 2017 Elsevier Ltd. All rights reserved.1 aPhilkhana, Satish, Chandra1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/total-synthesis-natural-fregenedadiol-and-its-diacetate-rearranged-labdanes-aromatized-b