01428nas a2200169   4500008004100000245008300041210006900124260000800193300001200201490000700213520084800220100001901068700001801087700001801105700002201123856011301145       2017                        eng d00aIron complex catalyzed selective C-H bond oxidation with broad substrate scope0 aIron complex catalyzed selective CH bond oxidation with broad su  cFEB  a746-7490 v193 a<p>The use of a peroxidase-mimicking Fe complex has been reported on the basis of the biuret-modified TAML macrocyclic ligand 'framework (Fe-bTAML) as a catalyst to perform selective oxidation of unactivated 3 degrees C-H bonds and activated 2 degrees C-H bonds with low catalyst loading (1 mol %) and high product yield (excellent mass balance) under near neutral conditions and broad substrate scope (18 substrates which includes arenes, heteroaromatics, and polar functional groups). Aliphatic C-H oxidation of 3 and 2 sites of complex substrates was achieved with predictable selectivity using steric, electronic, and stereoelectronic rules that govern site selectivity, which included oxidation of (+)-artemisinin to (+)-10 beta-hydroxyartemisinin. Mechanistic studies indicate Fe-V(O) to be the active oxidant during these reactions.</p>1 aJana, Sandipan1 aGhosh, Munmun1 aAmbule, Mayur1 aGupta, Sayam, Sen  uhttps://library.ncl.res.in/content/iron-complex-catalyzed-selective-c-h-bond-oxidation-broad-substrate-scope