01584nas a2200169   4500008004100000245007000041210006900111260000800180300001400188490000800202520101100210100001701221700002501238700002401263700002601287856010101313       2016                        eng d00aFungal cell membrane-promising drug target for antifungal therapy0 aFungal cell membranepromising drug target for antifungal therapy  cDEC  a1498-15100 v1213 aIncrease in invasive fungal infections over the past few years especially in immunocompromised patients prompted the search for new antifungal agents with improved efficacy. Current antifungal armoury includes very few effective drugs like Amphotericin B; new generation azoles, including voriconazole and posaconazole; echinocandins like caspofungin and micafungin to name a few. Azole class of antifungals which target the fungal cell membrane are the first choice of treatment for many years because of their effectiveness. As the fungal cell membrane is predominantly made up of sterols, glycerophospholipids and sphingolipids, the role of lipids in pathogenesis and target identification for improved therapeutics were largely pursued by researchers during the last few years. Present review focuses on cell membrane as an antifungal target with emphasis on membrane biogenesis, structure and function of cell membrane, cell membrane inhibitors, screening assays, recent advances and future prospects.1 aSant, D., G.1 aTupe, Santosh, Genba1 aRamana, Chepuri, V.1 aDeshpande, Mukund, V.  uhttps://library.ncl.res.in/content/fungal-cell-membrane-promising-drug-target-antifungal-therapy