01209nas a2200145   4500008004100000245018300041210006900224260000800293300001400301490000700315520057900322100001900901700001900920856012400939       2016                        eng d00aSynthesis of ophiocerins A, B and C, botryolide E, decarestrictine O, stagonolide C and 9-epi-stagonolide C employing chiral hexane-1,2,3,5-tetraol derivatives as building blocks0 aSynthesis of ophiocerins A B and C botryolide E decarestrictine   cSEP  a4696-47100 v273 aAn organocatalytic approach to the synthesis of (2R,3S)-hexane-1,2,3,5-tetraol (11) derivatives (in the forms of different stereoisomers and bearing different protecting groups) has been developed. The key chiral intermediates 11 were prepared with complete stereocontrol through the proline-catalyzed intermolecular aldol reaction between acetone and d-glyceraldehyde acetonide. The synthetic utility of the intermediates was demonstrated by their transformation into the title hydroxylated pyrans and a variety of unsaturated lactones through standard synthetic protocols.1 aShow, Krishanu1 aKumar, Pradeep  uhttps://library.ncl.res.in/content/synthesis-ophiocerins-b-and-c-botryolide-e-decarestrictine-o-stagonolide-c-and-9-epi