01752nas a2200145   4500008004100000245009500041210006900136260000800205300001200213490000600225520120000231100003001431700002501461856012001486       2014                        eng d00aAntimicrobial and dna damaging activity of ochratoxin a extracted from Penicillium species0 aAntimicrobial and dna damaging activity of ochratoxin a extracte  cOCT  a335-3410 v53 aThe present investigation was carried out by ten bacterial species, Bacillus subtilis, Escherishia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Micrococcus luteus, Pseudomonas aeruginosa, Pseudomonas putida, Proteus mirabilis, Proteus vulgaris, Staphylococcus aureus and five fungal species, Aspergillus terreus, Penicillium aurantiogriseum, P.expansum, Paceliomycs varioti, Fusarium graminarium were screened for their sensitivity against ochratoxin A (OTA) produced by Penicillium verrucosum. Proteus mirabilis was highly sensitive followed by E.aureogens, B.subtilis and K. pneumoniae. Rest of the bacteria was intermediate in their sensitivity when compared with the streptomycin as standard. Similarly P.aurantiogriseum and Paeciolomyces varioti were comparatively more sensitive than the other fungi under study. Aspergillus terreus and P.expansum was sensitive to an intermediate extent. Simultaneously the DNA damaging activity of OTA was also evaluated by PRSET-B plasmid DNA treated with H2O2 plus different concentrations of OTA. The highest DNA stand breaks was observed on even at 25μg/ml of OTA and complete degradation of DNA stand breaks was observed on 30μg/ml of OTA.1 aVankudoth, Koteswara, Rao1 aSivadevuni, Girisham  uhttps://library.ncl.res.in/content/antimicrobial-and-dna-damaging-activity-ochratoxin-extracted-penicillium-species