01747nas a2200205   4500008004100000245018000041210006900221260000800290300001000298490000600308520094500314100002201259700002501281700002301306700002101329700001901350700002501369700002101394856012601415       2014                        eng d00aDetermination of optimum values of descriptors to set filters for synthetic tri-pyrrole derivatives (prodiginines) against multi drug resistant strain of plasmodium falciparum0 aDetermination of optimum values of descriptors to set filters fo  cJAN  a51-590 v13 a<p>Abstract: In the present study, we have carried out extensive non-linear Quantitative-Structure Activity Relationship (QSAR) analysis to correlate in vitro anti-malarial activity against multi drug resistant strain of Plasmodium falciparum. Forty-three synthetic prodiginines with different structural features were used for their potential antimalarial activity. Linear, bilinear, biexponential and parabolic equations were developed. These equations were compared to determine the optimum values of descriptors for very useful and easily interpretable descriptors. The optimum values of these descriptors could be helpful in finding and optimizing a good lead compound. Obtained correlations reveal that various factors like lipophilicity, molecular weight and number of bonds have non-linear relation with the anti-malarial activity. Keywords: Prodiginines, Anti-Malarial Activity, Optimum/Desirability Values, Hybrid Inverse-QSAR</p>1 aMasand, Vijay, H.1 aMahajan, Devidas, T.1 aPourbasheer, Eslam1 aBen Hadda, Taibi1 aChauhan, Harsh1 aGajbhiye, Jayant, M.1 aAlafeefy, A., M.  uhttps://library.ncl.res.in/content/determination-optimum-values-descriptors-set-filters-synthetic-tri-pyrrole-derivatives