01083nas a2200145 4500008004100000245012000041210006900161260000800230300001400238490000700252520049800259100002600757700002400783856013000807 2017 eng d00aConcise approach for central core of trigolutes: total synthesis of trigolute B and 3-epi-trigolute B and analogues0 aConcise approach for central core of trigolutes total synthesis  cFEB a888 - 8990 v733 a

A concise approach comprising a combination of the Pd- or Ir-catalyzed Tsuji-Trost allylation and olefin dihydrox-ylation/acid catalyzed lactonization has been developed to construct the central spirolactone core of trigolutes with the requisite functional groups. A large number of analogues of trigolute B have been synthesized. Furthermore, the synthesis of both (±)-trigolute B and (±)-3-epi-trigolute B has been accomplished in 4–5 steps from easily accessible building blocks.

1 aReddy, Narendraprasad1 aRamana, Chepuri, V. uhttps://library.ncl.res.in/content/concise-approach-central-core-trigolutes-total-synthesis-trigolute-b-and-3-epi-trigolute-b