01529nas a2200181   4500008004100000245009000041210006900131260000800200300001000208490000600218520089800224100002901122700002101151700002401172700001901196700002101215856011101236       2015                        eng d00aAntimycobacterium activity of coumarins from fruit pulp of aegle marmelos (L.) correa0 aAntimycobacterium activity of coumarins from fruit pulp of aegle  cJUL  a39-440 v53 a<p>Phytochemical investigation of n-butanol fraction of acetone extract of Aegle marmelos fruit has afforded four compounds coumarins marmelosin (1), marmin (2) and xanthotoxol (3) and flavonoid kaempferol 3- O-rhamnoside, afzelin (4). All the isolated compounds were evaluated for their antimycobacterium activity against Mycobacterium tuberculosis H37Ra and Mycobacterium bovis. Compounds 1 and 2 exhibited antimycobacterium activity against M. tuberculosis H37Ra with an IC50 12.46 µg/mL and 4.31 µg/mL respectively whereas, at 100 µg/mL, 62.5% and 82.4% growth inhibition of M. bovis was observed respectively. Compounds 1 and 2 were also evaluated against two gram positive bacteria Staphylococcus aureus, Bacillus subtilis and one gram negative bacteria Escherichia coli. Compound 1 at 100 µg/mL, showed growth inhibition, 64.6% and 74.9% of E. coli and B. subtilis respectively.</p>1 aChinchansure, Ashish, A.1 aShamnani, Neelam1 aArkile, Manisha, A.1 aSarkar, Dhiman1 aJoshi, Swati, P.  uhttps://library.ncl.res.in/content/antimycobacterium-activity-coumarins-fruit-pulp-aegle-marmelos-l-correa