01427nas a2200133   4500008004100000245010100041210006900142260000800211490000600219520089900225100001801124700001901142856013201161       2015                        eng d00aMultifunctional silica nanoparticles for pancreatic cancer specific drug delivery and bioimaging0 aMultifunctional silica nanoparticles for pancreatic cancer speci  cJUN0 v23 a<p>Mesoporous silica nanoparticles (MSN) have attracted increasing interest as drug carriers due to their biocompatibility and robustness. In this analysis we explored the potential of MSN as nanotheranostic platform for pancreatic cancer specific drug delivery and bioimaging. Pancreatic cancer is the most fatal cancer and due to its high mortality and low prognosis it is imperative to develop new methods for early diagnosis and therapy of this cancer. Though traditionally organic dyes, quantum dots and fluorescent agents are used for bioimaging but here we have utilized graphene quantum dots (GQDs) for bioimaging due to their superior biocompatibility and fluorescence properties. MSN were loaded with gemcitabine; the most preferred drug for pancreatic cancer. MSN and GQDs were characterized by SEM, TEM, FT-IR etc and the efficacy of nanoformulation was determined by MTT assay.</p>1 aNigam, Preeti1 aSarkar, Dhiman  uhttps://library.ncl.res.in/content/multifunctional-silica-nanoparticles-pancreatic-cancer-specific-drug-delivery-and-bioimaging