01752nas a2200169   4500008004100000245017100041210006900212260000800281300001200289490000600301520106100307100002401368700002401392700001901416700002801435856011901463       2016                        eng d00aNaturally occurring anti-TB agents: isolation, chemical transformations and in vitro antitubercular activities of secondary metabolites of rhizomes of alpinia galanga0 aNaturally occurring antiTB agents isolation chemical transformat  cSEP  ae55-e590 v33 a<p>A bioactivity-guided chemical examination of the acetone extract of the rhizomes of Alpinia galanga led to the isolation of six sec-ondary metabolites, eucalyptol derivative (1)andphenylpropa-noids (2–6). The structures of all of the isolated compounds (1–6)wereelucidatedonthebasisoftheirspectraldata.Theisolatedcompounds (1–6)werein vitro assayed against active and dor-mant phenotypes of Mycobacterium tuberculosis H37Ra, respec-tively. Interestingly, 1′S-1′-acetoxychavicol acetate (2)showedgood antitubercular activities against both active and dormantphenotypes of M. tuberculosis with IC50 values of 1.04 µM and2.69 µM, respectively. Tsuji-Trost and homodimerization reac-tions of the active compound (2)respectivelyresultedinthefor-mation of two analogues, 7and 8.Bothofthesesynthesizedana-logues were also found to be active in vitro against active [IC50 sof3.24 and 3.87 µM, respectively, for compounds 7and 8]anddor-mant [IC50 sof8.33and2.41µM,respectively,forcompounds7and 8]phenotypesofM. tuberculosis H37Ra, respectively.</p>1 aValkute, Tushar, R.1 aArkile, Manisha, A.1 aSarkar, Dhiman1 aBhattacharya, Asish, K.  uhttps://library.ncl.res.in/content/naturally-occurring-anti-tb-agents-isolation-chemical-transformations-and-vitro