01521nas a2200145   4500008004100000245013400041210006900175260000800244300001600252490000600268520092100274100002801195700002501223856012701248       2015                        eng d00aCitrate modified beta-cyclodextrin functionalised magnetite nanoparticles: a biocompatible platform for hydrophobic drug delivery0 aCitrate modified betacyclodextrin functionalised magnetite nanop  cFEB  a22117-221250 v53 a<p>Water-dispersible magnetite nanoparticles functionalized with citric acid (CIT) modified beta-cyclodextrin (CD) are prepared and curcumin (CUR) is loaded inside the cavity of CD. The CUR loading capacity of CD-CIT functionalized magnetite nanoparticles is found to be much larger than that of CD alone as well as the CD-CIT conjugate. The release profile of curcumin is found to follow zero order kinetics at the physiological pH, and thus, can release CUR at a constant rate, after the initial burst release. Relaxivity studies using NMR showed that the functionalized nanoparticles are suitable for contrast enhancement in MRI. Thus, the water-dispersible, CIT modified beta-CD functionalized magnetite nanofluid is an efficient carrier for water insoluble curcumin, and can be used for magnetic drug targeting/delivery as well as for contrast enhancement in MRI due to the superparamagnetic magnetite core.</p>1 aJayaprabha, Kunnoth, N.1 aJoy, Pattayil, Alias  uhttps://library.ncl.res.in/content/citrate-modified-beta-cyclodextrin-functionalised-magnetite-nanoparticles-biocompatible