01512nas a2200157   4500008004100000245005100041210005100092260000800143300001400151490000600165520103500171100002501206700002101231700002301252856007901275       2011                        eng d00aSystems view of the protein expression process0 aSystems view of the protein expression process  cDEC  a139–1500 v53 a<p>Many biological processes are regulated by changing the concentration and activity of proteins. The presence of a protein at a given subcellular location at a given time with a certain conformation is the result of an apparently sequential process. The rate of protein formation is influenced by chromatin state, and the rates of transcription, translation, and degradation. There is an exquisite control system where each stage of the process is controlled both by seemingly unregulated proteins as well as through feedbacks mediated by RNA and protein products. Here we review the biological facts and mathematical models for each stage of the protein production process. We conclude that advances in experimental techniques leading to a detailed description of the process have not been matched by mathematical models that represent the details of the process and facilitate analysis. Such an exercise is the first step towards development of a framework for a systems biology analysis of the protein production process.</p>1 aGokhale, Sucheta, A.1 aNyayanit, Dimpal1 aGadgil, Chetan, J.  uhttps://library.ncl.res.in/content/systems-view-protein-expression-process