01372nas a2200169   4500008004100000245009700041210006900138260000800207300001600215490000600231520075600237100001800993700002201011700002401033700002001057856012501077       2016                        eng d00aUnified strategy for nickel-catalyzed C-2 Alkylation of indoles through chelation assistance0 aUnified strategy for nickelcatalyzed C2 Alkylation of indoles th  cJUL  a5666–56720 v63 a<p>A nickel-catalyzed direct C-2 alkylation of indoles through monodentate-chelation assistance has been described. This reaction proceeds via an unusual strategy by the use of a well-designed and defined (quinolinyl)amido–nickel catalyst, [{κN,κN,κN-Et2NCH2C(O)(μ-N)C9H6N}Ni(OAc)], providing a solution to the limitations associated with bidentate-chelate auxiliaries. The method allows coupling of indoles with various unactivated primary and secondary alkyl halides with ample substrate scope. This uniquely strategized alkylation proceeded through crucial C–H activation and via an alkyl radical intermediate. The reaction by this approach represents a rare example of Ni-catalyzed monodentate-chelate-assisted C–H functionalization.</p>1 aSoni, Vineeta1 aJagtap, Rahul, A.1 aGonnade, Rajesh, G.1 aPunji, Benudhar  uhttps://library.ncl.res.in/content/unified-strategy-nickel-catalyzed-c-2-alkylation-indoles-through-chelation-assistance