01382nas a2200169   4500008004100000245008000041210006900121260000800190300001800198490000800216520078100224100002501005700002801030700002501058700002001083856010901103       2010                        eng d00aDirect hydrogenation of amides to alcohols and amines under mild conditions0 aDirect hydrogenation of amides to alcohols and amines under mild  cNOV  a16756–167580 v1323 a<p>The selective, direct hydrogenation of amides to the corresponding alcohols and amines with cleavage of the C−N bond was discovered. The expected products of C−O cleavage are not formed (except as traces in the case of anilides). The reaction proceeds under mild pressure and neutral, homogeneous conditions using a dearomatized, bipyridyl-based PNN Ru(II) pincer complex as a catalyst. The postulated mechanism involves metal−ligand cooperation by aromatization−dearomatization of the heteroaromatic pincer core and does not involve hydrolytic cleavage of the amide. The simplicity, generality, and efficiency of this environmentally benign process make it attractive for the direct transformations of amides to alcohols and amines in good to excellent yields.</p>1 aBalaraman, Ekambaram1 aGnanaprakasam, Boopathy1 aShimon, Linda, J. W.1 aMilstein, David  uhttps://library.ncl.res.in/content/direct-hydrogenation-amides-alcohols-and-amines-under-mild-conditions