01330nas a2200193 4500008004100000245008000041210007100121260000800192300001400200490000700214520048400221653019300705100003000898700002400928700002000952700002300972700002500995856011601020 2016 eng d00aExpedient cobalt-catalyzed C–H alkynylation of (enantiopure) benzylamines0 aExpedient cobaltcatalyzed C–H alkynylation of enantiopure benzyl cOCT a5252-52550 v183 a

A unified strategy for cobalt-catalyzed ortho-C-H bond alkynylation of benzylamines is reported. Simple, commercially available CoBr2 was used as a cobalt source. The developed alkynylation strategy is robust and efficient and has a broad substrate scope including 1 degrees, 2 degrees, and 3 degrees benzylamines. The mechanistic study shows that C-H bond cleavage is reversible, and the kinetic study illustrates that the rate of reaction depends solely on the catalyst.

10aTerminal Alkynes; Bond Activation; Directed Functionalization;Aminoquinoline Benzamides; Ortho-C(Sp(2))-H Bonds; Mechanistic Insights; Selective Access; Carbon-Hydrogen; Nickel; Annulation1 aLandge, Vinod, Gokulkrish1 aMidya, Siba, Prasad1 aRana, Jagannath1 aShinde, Dinesh, R.1 aBalaraman, Ekambaram uhttps://library.ncl.res.in/content/expedient-cobalt-catalyzed-c%E2%80%93h-alkynylation-enantiopure-benzylamines